Possible Interaction: Histidine and Leucine

“A spectroscopic analysis of the interaction between L and R show that the binding pocket of R is large … 6 amino acids and that a fluorescein-labelled pentapeptide is quenched upon binding to R. We hypothesize that histidine 90 (putatively located in the extracellular … third transmembrane domains) protonates L ….”

“Incorporation of radioactively labelled leucine and histidine revealed some regional differences between the epithelia examined.”

“ Leucine , glycine, and histidine were responsible for increased biomass and leucine starvation in the presence of histidine was implicated in plasmid amplification.”

“It catalyzes antiport of His and some neutral amino acids such as Ile, Leu , Val, Cys, Met, Gln and Phe thus being involved in amino acid metabolism.”

“Supplementation of leucine resulted in increased concentrations of glucose, methionine, threonine, histidine and EAAs and decreased concentration of arginine in serum.”

“Probes based on cyclometalated iridium(III) complexes Ir(L)2(sol)2 (where L is 2-phenylpyridine, 2-(2,4-difluorophenyl)pyridine, or benzo[h]quinolone, and sol is a solvent molecule) present long-lived emission when bound to histidine.”

“Calculations suggested that, although histidine remained first-limiting when soya was included in the diet, any response to infusion of histidine was blocked by the rapidly emerging deficiency of another amino acid, probably leucine.”

“A 20-fold excess of unlabeled leucine, isoleucine, methionine, valine, alanine, lysine, histidine , phenylalanine, and glutamine inhibited uptake of leucine and phenylalanine, and six of these amino acids inhibited uptake of alanine, by more than 50% both in the presence and absence of a potassium ion gradient.”

“The Na+‐independent transport of leucine was subject to trans‐stimulation and was inhibited by the presence of excess phenylalanine, histidine , and, to a lesser extent, 2‐amino‐(2,2,1)‐bicycloheptane‐2‐carboxylic acid (BCH).”

“The presence of L -methionine reduces the amount of histidine present in the intestinal wall during absorption.”