Possible Interaction: Histidine and Iron, Dietary

“The binding of each iron protected two histidines from ethoxyformylation, and in both cases the proteins remained completely active.”

“In this study we discover that iron in the presence of histidine also enhanced cleavage of human immunoglobulin gamma (IgG) molecules containing a lambda light chain when incubated at 40 degrees C. The level of cleavage was concentration dependent on both iron and histidine levels.”

“The interaction of SDS with oxyHb suggests a conformational change of the protein in the heme pocket, which may induce the binding of distal histidine to iron leading to the formation of superoxide radical.”

“Because histidines can serve as ligands for the enzymatically active iron , this region may be critical to enzymatic function.”

“Addition of the zinc ligand, histidine , to the water solution decreased the inhibitory effect of the higher dose of iron , resulting in a zinc absorption of 47%.”

“Large differences in the mean-squared displacement, [x2]gamma, of the heme … and deoxyhemoglobin at temperatures above 210 K were observed, demonstrating that when iron is bound to a rigid … the protein (i.e., distal histidine in hemochrome), motions of the heme are … (i.e., the dynamics are decreased).”

“Supplementation with valine, ascorbic acid and histidine also increased intestinal Fe absorption in anaemic subjects, but to a lesser extent than in controls.”

“For the ferric N-fragment, close activation entropy values have been determined for the two histidines coordinated to the iron ; this result significantly differs from that for GuHCl-denatured cyt c, where largely different values of activation entropy were calculated.”

“Further, histidine maintains the electrochemical reversibility of iron.”

“The results indicate that among these three, the interaction of histidine with the iron center is strongest.”

“Herein, the use of histidine can increase the N and Fe contents in the product.”