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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Histidine
supplement:
Homocysteine
Research Papers that Mention the Interaction
“We demonstrate that filament formation is controlled by methylation and that histidine promotes re-methylation of homocysteine by donating one-carbon intermediates to the cytosolic folate cycle.”
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.“At pH 7.4 histidine is able to prevent LDL oxidation by copper(II) in a thiol mixture similar to the one found in human plasma if present in tenfold excess over homocysteine, but loses its inhibitory effect at higher homocysteine concentrations.”
“In …, homocysteine concentrations showed a direct … concentration of histidine (R2: .403, P < .001), valine (R2: .324, P < .01), leucine (R2: .400, P < .01), isoleucine (R2: .351, P < .005), cysteine (…, P < .001), methionine (R2: .256, P < .01), BCAA (R2: .50, P < .01), and essential amino acid (R2: .416, P < .01).”
“ L-Histidine also enhanced the excitatory action of L-glutamate, D- and L-aspartate, L-homocysteate and especially that of quisqualate, whereas the actions of acetylcholine, kainate, N-methyl-D-aspartate and D-homocysteate were more commonly reduced.”
L-Histidine: Effects on sensitivity of cat spinal neurones to amino acids
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