Possible Interaction: Histamine and Vitamin C

“Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration.”

“In these circumstances, acute and short-term treatment with vitamin C may increase the bronchoconstrictive response to inhaled histamine.”

“ Vitamin C depletion has been correlated with histaminemia which has been shown to damage endothelial-dependent vasodilation.”

“Furthermore, ascorbic acid may also control release of histamine and prostaglandins of the E and F types through its action on cyclic nucleotides and phosphodiesterase.”

“These data indicate that VC may indirectly enhance chemotaxis by detoxifying histamine in vivo.”

“Low levels of ascorbic acid may be essential to stimulate the synthesis and/or release of histamine while in high concentrations it may function to inhibit the release and/or to enhance the breakdown of excessive quantities of histamine in the body.”

“The results suggest that ascorbic acid acts as a modulator to control the synthesis and/or release of histamine in the body.”

“Oral administration of ascorbic acid (1 g daily for 3 days) to 11 selected volunteers resulted in a reduction of the blood histamine level in every instance.”

“ Ascorbic acid with relatively higher concentrations produced a dose-dependent relaxation in tracheal muscle submaximally precontracted with KCl, histamine , and carbachol.”

“At concentrations of more …) M, exogenously added Hm suppressed the Con A-dependent uptake of [3H]thymidine by the … significantly augmented the response at 10(-14) M. The addition of ascorbic acid (10(-8)-10(-5) M) to the culture suppressed … A-mediated HDC induction and inhibited Hm biosynthesis.”

“Administration of histamine caused an increase in the serum level of ascorbic acid , while it led to a transitory decrease in the hepatic level of the vitamin.”