Possible Interaction: Histamine and Tubocurarine

“Mivacurium, atracurium and tubocurarine caused 370%, 234% and 252% increases in plasma histamine concentrations at 1 min, respectively.”

“ Tubocurarine caused 240% and 210% increases in plasma concentration of histamine at 1 and 3 min, respectively.”

“It is possible that the patient was sensitive to histamine released by d-tubocurarine as she had a minor past history of bronchial asthma.”

“…,histamine enhanced the amplitude of the depolarizing … blocking the afterhyperpolarizing potential with d-tubocurarine or apamin, and in the presence of tetrodotoxin and d-tubocurarine or apamin, indicating a postsynaptic action of … on the depolarizing afterpotential that is not simply a reflection of a decrease in the afterhyperpolarizing potential.”

“The vertebrate HA receptor antagonist, cimetidine, and the nicotinic receptor antagonist, d-tubocurarine , but not other known vertebrate HA receptor antagonists, reversibly blocked the action of HA.”

“injections of tubocurarine (greater than 5 mg kg-1; corresponds to tubocurarine 4 X 10(-4) mol litre-1 in the plasma of the rats) evoked a phasic increase in plasma histamine concentration.”

“Abstract Compound 48/80 and tubocurarine , which are known to release mast cell histamine in vitro , increased the outflow of histamine from blood-perfused canine subcutaneous adipose tissue in situ .”

“Second and subsequent injections of either compound 48/80 or tubocurarine were much less effective in releasing histamine and lipolytic products, indicating tachyphylaxis; cross tachyphylaxis between compound 48/80 and tubocurarine also occurred.”

“A larger dose of d-tubocurarine (1 mg/kg) produced a profound fall in MAP (average decrease 78 mm Hg), followed by signs of histamine-induced catecholamine release (transient rebound increases in MAP, PP, and HR) and more than a four-fold increase in circulating histamine.”

“The muscle-paralyzing dose of d-tubocurarine (0.4 mg/kg) produced an average decrease in MAP of 44 mm Hg together with a marked decrease in SPGSA to 7.8 per cent of the control value and a twofold increase in blood histamine concentration.”