Possible Interaction: Histamine and Selenium

“Day-to-day changes in the concentrations of histamine required to provoke whealing responses equivalent to responses on the first day of testing averaged 1.8-fold (±0.6 SE).”

“The blinded study also … that the amount of histamine required to provoke a response equivalent to the … response increased from 2.5-fold (±0.8 SE ) after one dose to 17.2-fold (±4.7 SE) after three … and to 22.2-fold (±5.9 SE) after five doses.”

“When physiological concentrations of Na(+), Ca(2+), …(-) were in the bathing medium, application of histamine significantly increased total conductance as determined by stepping to 50 mV from a … of -30 mV. The current reversed at a membrane potential of -30 +/- 5 ( SE ) mV and current-voltage … exhibited outward rectification.”

“Baseline aerosol histamine challenge decreased airway area to 71 +/- 2% ( SE ) of the control value (P < 0.05).”

“Stimulation with 100 microM histamine resulted in a rise in intracellular calcium from an unstimulated level of 178 +/- 25 to 497 +/- 154 nM Ca2+ ( SE ; n = 14) and a return to base-line free calcium concentration within 1 min of stimulation.”

“Five … histamine solution caused lung lymph flow (QL) to … of 5.5 +/- 0.5 ( SE ) ml/h to 14.3 +/- 1.5 (P less than 0.05) and the lymph-to-plasma …) to increase from 0.63 +/- 0.02 to 0.72 +/- 0.02 (P less than 0.05).”

“In six pairs of membranes, … short-circuit conditions, histamine (10(-4) M) significantly increased the net flux toward … lumen of Cl- from 1.7 +- 0.5 SE to 2.4 +- 0.6 microneq/cm2-h and Na+ from -….4 +- 0.3 to 0.2 +- 0.3 microneq/cm2-h.”