Possible Interaction: Histamine and Secretin

“Gastrin I (150 pg/ml) stimulated histamine release to a peak of 10.6 +/- 4.6 ng/min, which was inhibited to 2.1 +/- 0.5 ng/min by secretin (40 pg/ml).”

“The … of secretin in a dose of 1 U per kg resulted in marked inhibition of acid secretion … by either pentagastrin in a dose of 0.12 μg per kg per hr or histamine acid phosphate in a dose of 0.02 mg … kg per hr in 10 subjects.”

“In 64 patients a significant positive correlation was found between the acid output in response to a maximal dose of histamine and the bicarbonate output in response to a submaximal dose of secretin , and between the corresponding volumes of aspirated gastric and duodenal juice.”

“ Secretin , CCK, and jejunal acidification prevented the formation of duodenal ulcerations in conscious cats infused with pentagastrin or histamine for 36 hours.”

“Administration of either secretin or CCK-8 simultaneously with histamine elevated the exocrine pancreatic secretion compared to the smaller response obtained when administered separately.”

“N methyl histamine was 5‐6 times more potent than histamine on a weight basis when infused on its own; and 1‐16 times more potent than histamine when given in the presence of secretin.”

“Outputs of acid in response to the smallest doses of desulphated caerulein, histamine and N methyl histamine increased significantly when secretin was infused (P less than 0‐05).”