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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Histamine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“ Histamine in concentrations of 25-100 microM inhibited enzyme activity uncompetitively with respect to S-adenosylmethionine.”
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin.“ SAMe is the most important methyl group donor and is consequently responsible for the methylation (inactivation) of histamine , upon which its antiphlogistic action is based.”
“The ralationships between SAMe and histamine are evident on at least one level: namely that SAMe serves as the methyl donor in the methyltransferase system that seems to represent the main catabolic pathway of endogenous brain histamine.”
SAMe and histamine.“Addition of S-adenosylmethionine to the incubation mixtures in-creased the inactivation rate of histamine in the lung of all species examined, in the intestinal mucosa of the ruminants and in the liver of the non-ruminants.”
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