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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Histamine and S-Adenosylmethionine

Research Papers that Mention the Interaction

Histamine in concentrations of 25-100 microM inhibited enzyme activity uncompetitively with respect to S-adenosylmethionine.
The Biochemical journal  •  1980  |  View Paper
SAMe is the most important methyl group donor and is consequently responsible for the methylation (inactivation) of histamine , upon which its antiphlogistic action is based.
MMW, Munchener medizinische Wochenschrift  •  1978  |  View Paper
The ralationships between SAMe and histamine are evident on at least one level: namely that SAMe serves as the methyl donor in the methyltransferase system that seems to represent the main catabolic pathway of endogenous brain histamine.
Monographien aus dem Gesamtgebiete der Psychiatrie  •  1978  |  View Paper
Addition of S-adenosylmethionine to the incubation mixtures in-creased the inactivation rate of histamine in the lung of all species examined, in the intestinal mucosa of the ruminants and in the liver of the non-ruminants.
Acta physiologica Scandinavica  •  1973  |  View Paper