Possible Interaction: Histamine and Quercetin

“In vivo, as compared with native protein, conjugation with QUE decreased the levels of IgE, IgG1, IgG, plasma histamine and mast cell protease-1 (mMCP-1) on the surface of sensitized mast cells, along with decreased FcεRI+ and c-kit+ expression.”

“C48/80, a histamine promoter , and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2‐induced pseudo‐allergic reaction.”

“Furthermore, it inhibited the vasodilation due to histamine, the release of eosinophils, and the percentage of degranulated mast cells, indicating that Quercetin antagonized mast cell mediators in vivo, histamine‐induced vasodilation and eosinophil release.”

“ARE, quercetin , and kaempferol inhibited secretion of β-hexosaminidase and histamine , and reduced the production and mRNA expression of interleukin-4 and tumor necrosis factor-α.”

“In in vitro assays, quercetin directly attenuated phospholipase C activity, decreased inositol phosphate synthesis, and decreased intracellular calcium responses to Gq-coupled agonists ( histamine or bradykinin).”

“ Que and cromolyn (100 µM) can effectively inhibit secretion of histamine and PGD2.”

“Indeed, quercetin significantly decreased the elevated plasma histamine content (P<0.05).”

“ Quercetin (10 mg/mL, inhalation for 2 min) significantly decreased histamine and protein contents, PLA2 activity, and recruitments of leukocytes in BALF and also improved slightly infiltration of eosinophils and neutrophils in histopathological survey.”

“significantly and dose-dependently inhibited both sRaw on IAR (31.60 and 26.44%) and LAR (29.87 and 28.69%) but with … (0.3 mg/kg), which inhibited IAR by 36.71 and 69.45%, and LAR by 67.23 and 0%, respectively, Quercetin … histamine , PLA2, and … LAR.”

“Here we show that the flavonoid quercetin , which inhibits mast cell secretion of histamine , also inhibited RBL cell proliferation and constitutive histamine release while it induced synthesis of rat mast cell protease (RMCP) II and triggered processes leading to accumulation of secretory granules.”

“ Quercetin and certain other flavonoids inhibit guinea pig isolated ileum contractions induced by acetylcholine, histamine , barium chloride, leukotriene B, and prostaglandin E2 (Middleton, 1984; Abdalla and Abu Zarga, 1987; Capasso et al., 1988, 1991).”