Possible Interaction: Histamine and Oxytocin

“ Histamine (0.5 mg sc) stimulated the release of AVP, OXT and cortisol in the control and hyperprolactinaemic groups alike.”

“The oxytocin level increased substantially in response to adrenaline, noradrenaline, serotonin, histamine , dopamine or K(+) treatment.”

“Central infusion of histamine or immunochallenge with LPS administered intraperitoneally increased oxytocin and vasopressin secretion four‐ and two‐fold, respectively.”

“Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats.”

“Administration of α‐ or β‐noradrenergic agonists, or histamine , increased OT release in the PVN.”

“Dialysis of the PVN with ACSF containing histamine significantly increased the release of OT systemically and centrally within the PVN.”

“The present studies investigated whether histamine also influences the central intranuclear release of OT , which is known to be important in the activation of OT neurons, and the possible interaction of histamine with norepinephrine in systemic and central OT release.”

“These data demonstrate that histamine acts within the PVN to increase both systemic and intranuclear release of OT.”

“These findings suggest that histamine induces systemic and intranuclear OT release by stimulating the release of norepinephrine.”

“We conclude that HA stimulates hypothalamic CRH and OT neurons by increasing mRNA levels, and this effect seems to be mediated via activation of both HA H1 and H2 receptors.”

“If, as previously reported, these histamine neurones can reduce the electrical activity of oxytocin neurones via H2 receptors, then they may have a dual effect, increasing the synthesis of oxytocin while inhibiting its premature release.”

“Thus, histamine acts centrally, via H1 receptors, during parturition and may have an excitatory effect on oxytocin release.”

“ HA , an H1 and an H2 receptor agonist, stimulated the OT secretion dose-dependently.”

“In addition, we have recently shown that centrally administered histamine (HA), which is a mediator of stress-induced release of ACTH and prolactin (PRL), stimulates OT secretion.”

“Restraint stress and HA but not LPS or insulin stress induced an increase in peripheral OT levels, whereas only LPS stress and HA caused an increase in circulating AVP levels.”

“We conclude (1) that HA stimulates OT secretion via activation of postsynaptic H1 and H2 receptors, and (2) that, in contrast to AVP, OT does not seem to be involved in HA- and restraint-stress-induced ACTH and PRL secretion.”

“ HA (270 nmol) infused intracerebroventricularly increased the expression of CRH, AVP, and OT mRNA in the paraventricular nucleus as well as that of OT mRNA in the supraoptic nucleus of the hypothalamus.”