Possible Interaction: Histamine and Niacin

“a) In mast cells isolated from the rat peritoneum we have shown that nicotinamide (40 mM) will reduce by 2/s rds the release of histamine produced by 0.4 ~g/ml of compound 48/80.”

“b) In the dog, in vivo, taken as its own control, a dose of 150 m s / k s nicotinamide will reduce, in certain cases, the release of histamine produced by the injection of 100 ms /ks of the peptone of Witte. (”

“a) In mast cells isolated from the rat peritoneum we have shown that nicotinamide (40 mM) will reduce by 2/s rds the release of histamine produced by 0.4 ~g/ml of compound 48/80.”

“b) In the dog, in vivo, taken as its own control, a dose of 150 m s / k s nicotinamide will reduce, in certain cases, the release of histamine produced by the injection of 100 ms /ks of the peptone of Witte. (”

“When given to STZ-treated mice, nicotinamide , an inhibitor of poly(ADP-ribose) synthetase, reduced both the elevation of blood glucose and the elevations of HDC activity and histamine production.”

“7 The present experiments strongly suggest that histamine can act as an antagonist to modulate nicotinic cholinergic transmission.”

“The antigen-induced release of histamine both in vitro from rat peritoneal cell suspensions containing mast cells actively sensitized with IgE antibody and in vivo from passively sensitized skin can be inhibited by relatively high doses of nicotinamide.”

“Abstract The present experiments confirm that nicotinamide partially inhibits the in vitro release of histamine from anaphylactically sensitized guinea pig lung on incubation with antigen.”

“However, nicotinamide , though it inhibits increased release of histamine , does not inhibit the increased uptake of oxygen.2.”

“ Nicotinamide analogs which are DPNase inhibitor, such as nicotinic acid, isonicotinic acid hydrazide, pyridine-3-sulfonic acid, and iproniazid, also inhibit histamine release by antigen in various degrees.6.”