Possible Interaction: Histamine and Methionine

“Moreover, histamine also concentration dependently inhibited M current in rat superior cervical ganglion (SCG) neurons by a similar mechanism.”

“We have measured rate constants for reactions of histamine chloramine with methionine , ascorbate, and GSH at pH 7.4, of 91 M(-1)s(-1), 195 M(-1)s(-1), and 721 M(-1)s(-1), respectively.”

“The addition of histamine to arteries without endothelium and pretreated with the histamine H2‐antagonist, cimetidine ( 10−5 M ), caused a concentration‐dependent contraction of the cranial arteries with Emax values between 86% and 29% and pEC50 values between 7.53 and 6.77.”

“The nitric oxide synthase inhibitor NG‐nitro‐L‐arginine methyl ester (L‐NAME, 3 10−5 M ) significantly inhibited the relaxant response to histamine in cerebral and temporal arteries (pIC50 values between 7.43 and 7.13).”

“In addition, histamine increased in a dose‐(from 10−5 to 10−3 M ) and time‐ (from 4h to 24 h) dependent fashion the IL‐6 synthesis by endothelial cells.”

“2) The release of histamine in gut in the mice of group H and M was significantly reduced. (”

“In the presence of 10−5 M metiamide a concentration-dependent stimulation of the enzyme by histamine was found.”

“The basal release of histamine was also suppressed after infusion of 10−6 M tetrodotoxin or i.p.”

“Bath-application of histamine at 10-4 or 10-5 M induced a small membrane depolarization accompanied by a slight decrease in membrane resistance and a reversible increase in spontaneous firing in all MVN cell types.”

“The second exposition to 10–3 M histamine produced a 38.8% reduction in cAMP production.¶Conclusion: Histamine appears to induce homologous and probably cAMP-dependent desensitisation of H2-receptors.”

“The H2-receptor blocker cimetidine 10−5 M ) and the Ca2+-channel antagonist verapamil (10−6 M) each attenuated the arrhythmogenic influence of histamine in SHR and WKY preparations.”