Possible Interaction: Histamine and Histidine

“Whole brain histamine is markedly increased byl-histidine administration, but only minimally byd-histidine.”

“Levels of histamine could be elevated by genitourinary bacterial catabolism of histidine , or by ingested histamine, and gastric mucosal cells could be a source [2].”

“In two patients having systemic mastocytosis, additional evidence of inhibition of biosynthesis of histamine included marked reduction in symptoms attributed to histamine, and prevention of symptomatic exacerbation associated with histidine loading.”

“ Histamine produced by bacteria through decarboxylation of histidine in spoiled foods such as fish is known to cause food poisoning.”

“Moreover, the precursor of HA, L-histidine (1 g/kg), produced an increase of HA in the hypothalamus to 166% and the cortex to 348%.”

“The results of the present study demonstrated that insufficient intake of histidine reduced the brain histamine content, leading to anxiety-like behaviors in the mice.”

“Although histidine did not have a marked effect on ruminal fermentation, increased concentrations of histamine were observed following feeding.”

“At this dose, histidine caused a significant increase in the histamine content of the cortex, hippocampus, and hypothalamus in rats.”

“ Histamine content in fish may increase by decarboxylation of free histidine to values that can be toxic, if storage conditions are not well controlled.”

“The whole brain level of histamine , which was 50 ng/g, was increased byl-histidine and the highest concentration of histamine was found in the hypothalamus.”