Possible Interaction: Histamine and Genistein

“ Genistein at 10(-4) M increased the histamine content per 2 x 10(5) cells at day 3 from 5.9 +/- 1.2 micrograms/mL to 11.1 +/- 1.3 micrograms/mL (n = 6; p < 0.0001).”

“ Genistein , but not the less active analogue daidzein, dose-dependently attenuated PGI2 release in response to thrombin and histamine (IC50 approx.”

“These data suggest that genistein protected against gastric mucosal injury, likely via its ability to inhibit oxidation, inflammation, and secretion of gastrin and histamine.”

“The positive inotropic effect of histamine was depressed in a concentration‐dependent manner by the tyrosine kinase inhibitors tyrphostin A25 (50 to 100 μM) and genistein (10 to 50 μM) but not by the inactive genistein analogue daidzein (50 μM).”

“ Genistein and tyrphostin 47 concentration-dependently (10-100 microM) inhibited OA-induced anaphylactic contraction of the bronchi, as well as release of histamine and peptidoleukotrienes from chopped lung preparations.”

“ Genistein , but not tyrphostin 47, significantly suppressed bronchial contraction to leukotriene D4 at 50 microM and to histamine at 100 microM. Daidzein, an inactive congener of genistein, did not alter OA-induced anaphylactic contraction.”

“ Genistein proved to be a potent inhibitor of anti-IgE-induced histamine release in human basophils, though less potent in human lung mast cells.”