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“In medium containing 0 mM Ca2+, 2 mM Co2+ and 1-2 microM tetrodotoxin, with internal Ca2+ chelation, bath application of histamine induced an apparent inward current in 15 of 20 supraoptic neurons tested.”
“The transition metal ions Co2+ , Mn2+, and Ni2+, but not the nontransition ions (Cd2+, Sn2+ and Zn2+, markedly inhibited ACh and histamine relaxations in the aorta, whereas all metal ions antagonized KCI contractions.”