Possible Interaction: Histamine and Calcium Supplement

“ Histamine increased ECV304 cell calcium to 600 nM. Histamine did not increase myosin light chain phosphorylation of control or transfected ECV304 cells.”

“With prior addition of histamine (1 microM) and Ca2+ (4.5 mM) in equiinotropic concentrations, MEG and carbachol decreased contractility to a greater extent in the histamine-stimulated muscles.”

“ Histamine elicited repetitive … in intracellular Ca 2 + concentration in hCMEC/D3 cells throughout a concentration range spanning from 1 pM up to 300 μM. The oscillatory Ca 2+ response was suppressed by the inhibition of H 1Rs with pyrilamine, whereas H 1R was abundantly expressed at the protein level.”

“ Histamine produced a dose dependent increase of [ Ca2+i ], maximal at 1.0 mmol/l which recovered to the pre-challenge resting value.”

“HeLa cells stimulated with histamine exhibited a considerable variation in the temporal pattern of Ca2+ signals and we found that there were cell-specific IP3 dynamics depending on the patterns of Ca2+ signals.”

“The enhanced invasion induced by histamine was blocked by pretreatment with H1 antagonist or by chelation of Ca2+i.”

“It is concluded that the intestinal epithelial cell has three distinct types of K+ conductance and that histamine modulates not only Ca2+-activated K+ conductance via Ca2+ mobilization, but also inward- and outward-rectifier K+ conductances via activation of protein kinase C.”

“Application of histamine induced an intracellular calcium transient and an ionic current that reversed near 0 mV. The amplitude of the current ranged from −0.2 to −2nA at −100mV. The tonic rise in [Ca2+]i and the ionic current are partly due to Ca2+ influx.”

“However, lower concentrations of histamine also caused mobilization of calcium that were totally abolished by pre-incubation with H1 but not H2 or H3 receptor antagonists.”

“ Histamine induced calcium -dependent changes to the cytoskeleton and cellular organization, including increased actin stress fibers.”