Possible Interaction: Histamine and Adrenocorticotropic Hormone

“ Histamine stimulates the secretion of ACTH , beta-endorphin (mediated by CRH and AVP), alpha-MSH (mediated by dopamine and peripheral catecholamines), and PRL (mediated by dopamine, serotonin and AVP), and participates in the stress-induced release of these hormones and possibly in the suckling- and estrogen-induced PRL release.”

“One known central effect of HA is the stimulation of ACTH and corticosteroid release.”

“Our findings support the concept of an excitatory influence of histamine upon ACTH secretion via H1 receptors, possibly by stimulation of CRF release.”

“ HA significantly stimulated both ACTH and cortisol secretion, and this stimulation was probably mediated through H2 -receptors, H2 -receptor blockade caused a late, but significant ACTH release.”

“The results support the theory that HA acts as a modulator of human ACTH secretion.”

“These results suggest that histamine is involved in the control of ACTH secretion, possibly by stimulation of CRF release.”

“The intraperitoneal administration of ACTH decreased the IL-10, IgE and histamine levels in the plasma and mast cell number in NALT, while increasing the IFN-γ level and suppressing the incidence of nasal rubbing.”

“Since histamine is presumed to regulate the hypothalamic hormone release [6-8] the question was asked whether endogenous histamine , released in large quantities in thioperamide-treated PCA rats, would modulate plasma levels of adrenocorticotropin (ACTH) and prolactin (PRL).”

“The findings indicate that HA and some PGs in the brain interact in their stimulatory regulation of ACTH secretion.”

“Intracerebroventricular infusion of HA (34-540 nmol) increased the plasma levels of ACTH and beta-END immunoreactivity (beta-ENDir) in a dose-dependent manner.”

“ Histamine , which acts as a neurotransmitter, stimulates the release of the pro-opiomelanocortin derived peptides ACTH , beta-lipotropin, and beta-endorphin.”