Possible Interaction: Hiperforina and St John's Wort

“Hypericins, hyperforin and flavonoids are discussed as the main components contributing to the antidepressant action of St. John's wort (Hypericum perforatum).”

“ Hyperforin seems to be the major ingredient responsible for CYP and P-gp inducing activity of SJW ; thus, hyperforin-free products may be future candidates to decrease SJW’s drug interactions.”

“Many constituents may be responsible for the anti-inflammatory activity of Hp including quercetin and derivatives, hyperforin , pseudohypericin, and amentoflavone.”

“ Hyperforin may also have an important contribution to the antidepressant activity of Hypericum extracts.”

“ Hyperforin , which is believed to contribute to the antidepressant action of St John’s wort , is also strongly suspected to be responsible of most of the described interactions.”

“ Hyperforin is considered to be a primary cause of the inductive effect of St. John's wort.”

“The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum.”

“Conclusions St. John's wort and hyperforin concordantly affected expression of genes not only mediating metabolism and transport of exogenous and endogenous compounds, but also involved in energy metabolism, intracellular calcium regulation, cell proliferation and apoptosis.”

“Furthermore, it has been suggested in preclinical and clinical studies that the content of hyperforin but not of hypericin decisively contributes to the antidepressant efficacy of hypericum extracts.”

“ Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts.”

“This suggests that hyperforin plays a role in the antidepressant-like effect of the ester and of Hypericum extract.”