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Last Updated: 2 years ago

Possible Interaction: Hiperforina and St John's Wort

Research Papers that Mention the Interaction

Hypericins, hyperforin and flavonoids are discussed as the main components contributing to the antidepressant action of St. John's wort (Hypericum perforatum).
Arzneimittel-Forschung  •  2005  |  View Paper
Hyperforin seems to be the major ingredient responsible for CYP and P-gp inducing activity of SJW ; thus, hyperforin-free products may be future candidates to decrease SJW’s drug interactions.
Expert opinion on drug metabolism & toxicology  •  2017  |  View Paper
Many constituents may be responsible for the anti-inflammatory activity of Hp including quercetin and derivatives, hyperforin , pseudohypericin, and amentoflavone.
Critical reviews in food science and nutrition  •  2014  |  View Paper
Hyperforin may also have an important contribution to the antidepressant activity of Hypericum extracts.
Current medicinal chemistry  •  2013  |  View Paper
Hyperforin , which is believed to contribute to the antidepressant action of St John’s wort , is also strongly suspected to be responsible of most of the described interactions.
The AAPS Journal  •  2009  |  View Paper
Hyperforin is considered to be a primary cause of the inductive effect of St. John's wort.
Drug Metabolism and Disposition  •  2005  |  View Paper
The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum.
CNS drug reviews  •  2004  |  View Paper
Conclusions St. John's wort and hyperforin concordantly affected expression of genes not only mediating metabolism and transport of exogenous and endogenous compounds, but also involved in energy metabolism, intracellular calcium regulation, cell proliferation and apoptosis.
Pharmacogenetics and genomics  •  2005  |  View Paper
Furthermore, it has been suggested in preclinical and clinical studies that the content of hyperforin but not of hypericin decisively contributes to the antidepressant efficacy of hypericum extracts.
Der Nervenarzt  •  2002  |  View Paper
Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts.
This suggests that hyperforin plays a role in the antidepressant-like effect of the ester and of Hypericum extract.
European Neuropsychopharmacology  •  2005  |  View Paper
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