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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hexobarbital
supplement:
Melatonin
Research Papers that Mention the Interaction
“The oxidase function was also inhibited: luminol amplified chemiluminescence was more inhibited than the lucigenin amplified one, hydrogen peroxide formation was … than 10−4 M, microsomal NADPH/Fe stimulated lipid peroxidation was inhibited at concentrations higher than 105 M.In vivo melatonin … hexobarbital sleeping time in rats … manner (ip.”
Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment“ Hexobarbital half-life in plasma was prolonged 6 to 7 times by prior treatment with MIH (400 mg/kg).”
“Liver microsomes from mice treated with MIH exhibited decreased metabolism of the following substrates in vitro: hexobarbital , aminopyrine, ethylmorphine, and aniline.”
“ MIH (400 mg/kg) increased the period of sleep following hexobarbital (100 mg/kg) nearly 10-fold.”
The potentiation of barbiturate-induced narcosis by procarbazine.
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