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“The results presented here indicate that hyperphysiological levels of hexestrol cause a marked alteration in the means whereby nicotinate is converted to nicotinamide in mice.”
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine • 1970 | View Paper
“Abstract The daily administration of a hyperphysiological, nontoxic level (10 mg/kg) of hexestrol to mice, for 6 consecutive days, progressively lowered the capacity of hepatic tissue to synthesize NAD upon nicotinamide challenge.”