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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
Research Papers that Mention the Interaction
“In the present paper, preliminary data are reported showing that doses of lindane as low as those found in the female genital tract secretions inhibit the sperm cytological responsiveness to progesterone , the physiological agonist which stimulates the onset of acrosome reactions at the site of fertilization.”
Effects of organochlorine xenobiotics on human spermatozoa.“The other chemicals which decreased progesterone activity were endosulfan II, endosulfan sulfate, and lindane.”
“In addition, lindane suppressed the FSH and TGF beta1-stimulated increases in progesterone production and the levels of P450scc enzyme and StAR protein.”
Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells.“We report that gammexane (γ-chlorocyclohexane), an inositol analog, strongly inhibits progesterone action, providing a new tool for studying the effect of steroid on meiosis.”
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