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Possible Interaction: Hexachlorocyclohexane and Glutathione

Research Papers that Mention the Interaction

Findings that lindane induced GSH oxidation to GSSG with increased S-glutathionylation, together with the diamide and BCNU results, suggest that oxidation of GSH to GSSG is a component of the mechanism by which lindane inhibits myometrial gap junctions.
Lindane substantially increased S-glutathionylation in a concentration-dependent manner, measured biochemically by GSSG reductase-stimulated release of GSH from precipitated proteins.
Toxicological sciences : an official journal of the Society of Toxicology  •  2005  |  View Paper
Moreover, single- and repeated-dose treatments of mice with lindane decreased the GSH levels by 40 and 54%, respectively, and induced GST activity by 25 and 41%, respectively.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes  •  2004  |  View Paper
Cerebral contents of glutathione and ascorbic acid were decreased in response to HCH.
Neurochemical Research  •  1998  |  View Paper
One of the four glutathione-S-transferases (GST) that is overproduced in the insecticide-resistant Cornell-R strain of the housefly (Musca domestica) produces an activity that degrades the insecticide dimethyl parathion and conjugates glutathione to lindane.
Journal of Molecular Evolution  •  1996  |  View Paper
It is concluded that lindane enhances GSH synthesis in rat liver 24 h after treatment as a consequence of the decrement in its content observed at early times of intoxication (4 h), thus allowing the recovery of the normal level of hepatic GSH.
lindane (60 mg/kg) to … diminished the content of hepatic glutathione (GSH) 4 h after treatment, which was recovered at 24 h. At these experimental times, the activities of glutathione … reductase, glutathione-S-transferases and gamma-glutamyltransferase in the liver of lindane-treated rats and control animals were comparable.
Toxicology letters  •  1993  |  View Paper
The hepatic content of total GSH equivalents (GSH + 2GSSG) decreased 4 h after lindane treatment (60 mg/kg), together with significant diminution in net and fractional rates of sinusoidal GSH efflux, that returned to control values 24 h after treatment.
Xenobiotica; the fate of foreign compounds in biological systems  •  1991  |  View Paper
The concentration of reduced glutathione in the erythrocytes of rats was significantly decreased 24-72 hr after the rats were treated with 300 mg commercial hexachlorocyclohexane/kg body weight (one-third of the LD50), given ip.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  1991  |  View Paper
Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22%) and GSSG was increased (20%), while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished.
Xenobiotica; the fate of foreign compounds in biological systems  •  1988  |  View Paper
Lead + lindane treatments increased liver glutathione levels in the methionine-sufficient and methionine-deficient rats in both experiments.
Drug-nutrient interactions  •  1986  |  View Paper
Injection of glutathione into locusts reduces their mortality to lindane.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1985  |  View Paper