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Last Updated: 5 years ago
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“ Lindane exerts a stimulating action on synaptic transmission and inhibits the chloride current activated by gamma-amino butyric acid (GABA) of many muscular and nervous preparations by interacting with the receptors GABA-chloride channel complex.”
[Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane].“When co-applied with GABA, gamma-HCH strongly suppressed the peak amplitude of GABA-induced current, and delta-HCH strongly enhanced it in the alpha 1 beta 2 gamma 2s, alpha 1 beta 2, alpha 6 beta 2 gamma 2s combinations in a dose-dependent manner.”
“ Lindane , a widely used pesticide and scabicide, evokes seizures mainly through the blockade of the γ-aminobutyric acid type A receptor complex.”
Influence of NR2B-Selective NMDA Antagonist on Lindane-Induced Seizures in Rats“It was also found that prolonged pre-application of EBOB and gamma-HCH prior to co-application with GABA and glutamate resulted in enhanced blocking actions, indicating resting-state actions of the blockers.”
“Both lindane (gamma-hexachlorocyclohexane), an organochlorine ectoparasiticide and pentylenetetrazol, used as a model of experimental epilepsy, produce convulsive seizures resulting from the blockade of the gamma-aminobutyric acid (GABAA) receptor.”
“In the latter case, GABA reduced the lindane‐induced cytotoxicity, but the protective effect was not potentiated by flunitrazepam.”
“Both dieldrin and another organochlorine insecticide, lindane , block the effects of GABA on the GABAA receptor by binding directly to the Cl– channel.”
“A significant increase (p < 0.01) in GABA levels in cerebellum and significant increase in benzodiazepine receptors in cerebellar membrane measured by (3H)flunitrazepam binding were observed in the animals exposed to 3 and 5 mg lindane.”
“When co-applied with 10 microM GABA , 1 microM gamma-HCH slightly enhanced and then suppressed the GABA-induced chloride current.”
“A detailed analysis of the gamma-BHC action in the concentration-response relationship for GABA revealed that the IGABA with strong desensitization was preferentially blocked by gamma-BHC (3 x 10(-5) M).”
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