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Last Updated: 4 months ago

Possible Interaction: Hexachlorocyclohexane and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

When co-applied with GABA, gamma-HCH strongly suppressed the peak amplitude of GABA-induced current, and delta-HCH strongly enhanced it in the alpha 1 beta 2 gamma 2s, alpha 1 beta 2, alpha 6 beta 2 gamma 2s combinations in a dose-dependent manner.
Brain Research  •  1996  |  View Paper
It was also found that prolonged pre-application of EBOB and gamma-HCH prior to co-application with GABA and glutamate resulted in enhanced blocking actions, indicating resting-state actions of the blockers.
Invertebrate neuroscience : IN  •  2005  |  View Paper
Both lindane (gamma-hexachlorocyclohexane), an organochlorine ectoparasiticide and pentylenetetrazol, used as a model of experimental epilepsy, produce convulsive seizures resulting from the blockade of the gamma-aminobutyric acid (GABAA) receptor.
Toxicology letters  •  2004  |  View Paper
Both dieldrin and another organochlorine insecticide, lindane , block the effects of GABA on the GABA(A) receptor by binding directly to the Cl- channel.
Developmental neuroscience  •  1998  |  View Paper
A significant increase (p < 0.01) in GABA levels in cerebellum and significant increase in benzodiazepine receptors in cerebellar membrane measured by (3H)flunitrazepam binding were observed in the animals exposed to 3 and 5 mg lindane.
Drug and chemical toxicology  •  1998  |  View Paper
When co-applied with 10 microM GABA , 1 microM gamma-HCH slightly enhanced and then suppressed the GABA-induced chloride current.
Brain Research  •  1995  |  View Paper
Like picrotoxinin, lindane (10, 30 microM) caused a dose-related shift to the right of the concentration-response curve to GABA , 3-APS and ivermectin with depression of the maximum response.
European journal of pharmacology  •  1993  |  View Paper
These results show that the convulsions elicited by lindane can be facilitated by some GABA antagonists and antagonized by GABA mimetics, especially those that enhance GABA functionality.
Toxicology and applied pharmacology  •  1989  |  View Paper
The pulsed application of 10(-3) M gamma-aminobutyric acid GABA ) elicited an inward CL- current of several 100 pA, which could be reversibly reduced by the simultaneous application of lindane or picrotoxin.
Brain Research  •  1989  |  View Paper
Comparison of lindane to other convulsants revealed that lindane mimicked the changes produced in dentate gyrus responses by GABA antagonist drugs including picrotoxin, pentylenetetrazol and bicuculline.
Neurotoxicology  •  1987  |  View Paper
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