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Possible Interaction: Hesperidin and Nitric Oxide



Research Papers that Mention the Interaction

Total leukocyte counts; nitric oxide production, iNOS expression, and proteins were significantly decreased by hesperidin.
Life sciences  •  2007  |  View Paper
5 In summary, we have demonstrated that hesperidin inhibits strain‐induced ET‐1 secretion and enhances NO production in HUVEC.
The aims of the present study were to test the hypothesis that hesperidin may alter strain‐induced ET‐1 secretion and NO production and to identify the putative underlying signalling pathways in human umbilical vein endothelial cells (HUVEC).
Clinical and experimental pharmacology & physiology  •  2008  |  View Paper
Hesperidin also showed anti-oxidative properties through the significant (p < 0.05) reduction of NO , hydroperoxides, and thiobarbituric acid reactive substances and increase of glutathione, glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in the organs.
Immunopharmacology and immunotoxicology  •  2016  |  View Paper
Morin and/or hesperidin pretreatment prevent oxidative stress in kidney tissue, while they increase the NOx level, CAT activity, and decrease MPO activity.
Renal failure  •  2016  |  View Paper
On the contrary, rats pretreated with MTZ and HSP showed significant decrease in NO , MDA levels, and MPO activity, while, activities of SOD and GPx were increased (P < 0.001).
Experimental biology and medicine  •  2015  |  View Paper
Hesperidin treatment decreased NO , IL-10, IL-12, and TNF-alpha levels by 56 %, 47 %, 29 %, and 63 %, respectively.
Hesperidin treatment increased IL-12 levels by 72 % and strongly decreased the NO secretion.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  2013  |  View Paper
The results highlight the involvement of nitric oxide mechanism in the protective effect of hesperidin against ischemia reperfusion injury induced alterations.
Indian journal of experimental biology  •  2011  |  View Paper
NO production induced by high glucose was significantly inhibited by hesperidin.
Advances in experimental medicine and biology  •  2010  |  View Paper
Thus, the flavonoids quercetin and hesperidin exert a distinct antioxidant action, substantialy suppressing the hepatosis-induced increase in the intensity of NO radical generation.
Biofizika  •  2005  |  View Paper
HSP and/or TAU significantly depressed CCl 4 -induced elevation of alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, …, α2, β, and γ), albumin/globulin ratio, triglycerides, total cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, nitric oxide, ….
Environmental Science and Pollution Research  •  2020  |  View Paper
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