supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Hesperidin
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“… HSP and/or TAU significantly depressed CCl 4 -induced elevation of alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, …, α2, β, and γ), albumin/globulin ratio, triglycerides, total cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, nitric oxide, ….”
Single or combined protective and therapeutic impact of taurine and hesperidin on carbon tetrachloride-induced acute hepatic injury in rat“Total leukocyte counts; nitric oxide production, iNOS expression, and proteins were significantly decreased by hesperidin.”
“5 In summary, we have demonstrated that hesperidin inhibits strain‐induced ET‐1 secretion and enhances NO production in HUVEC.”
“The aims of the present study were to test the hypothesis that hesperidin may alter strain‐induced ET‐1 secretion and NO production and to identify the putative underlying signalling pathways in human umbilical vein endothelial cells (HUVEC).”
“ Hesperidin also showed anti-oxidative properties through the significant (p < 0.05) reduction of NO , hydroperoxides, and thiobarbituric acid reactive substances and increase of glutathione, glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in the organs.”
Hesperidin prevents lipopolysaccharide-induced endotoxicity in rats“Morin and/or hesperidin pretreatment prevent oxidative stress in kidney tissue, while they increase the NOx level, CAT activity, and decrease MPO activity.”
“On the contrary, rats pretreated with MTZ and HSP showed significant decrease in NO , MDA levels, and MPO activity, while, activities of SOD and GPx were increased (P < 0.001).”
“ Hesperidin treatment decreased NO , IL-10, IL-12, and TNF-alpha levels by 56 %, 47 %, 29 %, and 63 %, respectively.”
“ Hesperidin treatment increased IL-12 levels by 72 % and strongly decreased the NO secretion.”
“The results highlight the involvement of nitric oxide mechanism in the protective effect of hesperidin against ischemia reperfusion injury induced alterations.”
“ NO production induced by high glucose was significantly inhibited by hesperidin.”
“Thus, the flavonoids quercetin and hesperidin exert a distinct antioxidant action, substantialy suppressing the hepatosis-induced increase in the intensity of NO radical generation.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback