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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Hesperidin
Research Papers that Mention the Interaction
“l-arginine and l-NAME attenuated and potentiated the effect of a lower dose of hesperidin , respectively.”
Abstracts of the Combined Meeting of the 6th Asia Pacific Conference Against Stroke and the 20th Stroke Society of Australasia. September 6-10, 2009. Cairns, Australia.“ Hesperidin or captopril significantly prevented the development of hypertension in l-NAME rats.”
Hesperidin Prevents Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via Suppressing TGF-β1 and MMPs Protein Expression“ Hesperidin (0.01mg/kg, a sub-effective dose in acute treatment) produced an additive antidepressant-like effect with N(G)-nitro-l-arginine (an inhibitor of nitric oxide synthase (NOS)) or 7-nitroindazole (a neuronal NOS inhibitor) in the TST.”
“Further, treatment with l-arginine (100 mg/kg) or l-NAME (10 mg/kg) in combination with hesperidin significantly modulated the protective effect of hesperidin which was significant as compared to their effects per se in PTZ-treated animals.”
“L-arginine (100 mg/kg) or L-NAME (10 mg/kg) pretreatment with lower dose of hesperidin (50 mg/kg) significantly reversed or potentiated its protective effect, respectively which was significant as compared to hesperidin (50 mg/kg).”
“However, L-NAME pretreatment significantly potentiated the protective effect of hesperidin.”
“Whereas L-NAME (10 mg/kg), a non-selective NOS inhibitor pretreatment with hesperidin (50 mg/kg) and naringin (50 mg/kg) significantly potentiated their protective effect which was significant as compared to their effect per se.”
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