Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Hesperidin and Ng-Nitroarginine Methyl Ester

Research Papers that Mention the Interaction

l-arginine and l-NAME attenuated and potentiated the effect of a lower dose of hesperidin , respectively.
International journal of stroke : official journal of the International Stroke Society  •  2009  |  View Paper
Hesperidin or captopril significantly prevented the development of hypertension in l-NAME rats.
Nutrients  •  2018  |  View Paper
Hesperidin (0.01mg/kg, a sub-effective dose in acute treatment) produced an additive antidepressant-like effect with N(G)-nitro-l-arginine (an inhibitor of nitric oxide synthase (NOS)) or 7-nitroindazole (a neuronal NOS inhibitor) in the TST.
Brain Research Bulletin  •  2014  |  View Paper
Further, treatment with l-arginine (100 mg/kg) or l-NAME (10 mg/kg) in combination with hesperidin significantly modulated the protective effect of hesperidin which was significant as compared to their effects per se in PTZ-treated animals.
Epilepsy & Behavior  •  2013  |  View Paper
L-arginine (100 mg/kg) or L-NAME (10 mg/kg) pretreatment with lower dose of hesperidin (50 mg/kg) significantly reversed or potentiated its protective effect, respectively which was significant as compared to hesperidin (50 mg/kg).
Indian journal of experimental biology  •  2011  |  View Paper
However, L-NAME pretreatment significantly potentiated the protective effect of hesperidin.
Pharmacological reports : PR  •  2010  |  View Paper
Whereas L-NAME (10 mg/kg), a non-selective NOS inhibitor pretreatment with hesperidin (50 mg/kg) and naringin (50 mg/kg) significantly potentiated their protective effect which was significant as compared to their effect per se.
Behavioural Brain Research  •  2010  |  View Paper