“A synergistic interaction was also observed when antinociceptive doses of hesperidin were combined with those of ketorolac producing 15 combinations mainly in additive and supra-additive responses.”
“These results provide evidence for the antinociceptive activity of hesperidin and demonstrate synergistic response when combined with ketorolac , possibly by involvement of the TRPV1 receptor, suggesting their clinical potential in pain therapy.”