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Last Updated: 2 months ago

Possible Interaction: Hesperidin and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

The use of HES as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.
Tumor Biology  •  2015  |  View Paper
Hesperidin and naringenin increased cytotoxicitity of doxorubicin on MCF-7 cells and HeLa cells.
Asian Pacific journal of cancer prevention : APJCP  •  2012  |  View Paper
Our results demonstrated that hesperidin inhibits proliferation of Ramos cells and sensitizes them to doxorubicin-induced apoptosis through inhibition of both constitutive and doxorubicin-mediated NF-κB activation in a PPARγ-independent manner.
We found that incubation of Ramos cells with hesperidin abrogates constitutive and doxorubicin-induced NF-κB activation through inhibition of phosphorylation of its inhibitory subunits (IκB).
European journal of pharmacology  •  2011  |  View Paper
Hesperidin and doxorubicin in combination prolonged the life span of EAC tumor-bearing mice which was associated with a decrease in the number of viable tumor cells and increases in dead tumor cells number.
In addition, co-administration of hesperidin with doxorubicin ameliorated the alteration in serum ALT, AST, ALP, GGT and LDH activities, total protein, albumin, creatinine, urea and total lipids concentrations.
Chemico-biological interactions  •  2018  |  View Paper
On the other hand, pretreatment of rats with hesperidin protected cardiac tissues against the cardiotoxic effects of doxorubicin as evidenced from amelioration of histopathological changes and normalization of cardiac biochemical parameters.
Journal of the Egyptian National Cancer Institute  •  2009  |  View Paper
In conclusion, both apigenin and hesperidin enhance the cytotoxic effects of doxorubicin on breast cancer cells, and this phenomenon occurs regardless of oxidative stress but is accompanied by disorders of DNA damage response mechanisms.
Molecules  •  2020  |  View Paper
ResultsThe apigenin and the hesperidin revealed the strongest effect on the toxicity of doxorubicin.
BMC Pharmacology and Toxicology  •  2019  |  View Paper
Co-chemotherapy application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression.
Hesperidin did not increase the apoptotic induction, but decreased the Pgp expressions level when combined with doxorubicin in low concentration.
Asian Pacific journal of tropical biomedicine  •  2014  |  View Paper