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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Hesperidin
drug:
Cpt-11
Research Papers that Mention the Interaction
“The results from this present study suggest that hesperidin may reduce the exposure of CPT‐11 and SN‐38 in the intestine by reducing the amount of biliary excretion of CPT‐11 and SN‐38.”
“These results indicate that oral administration of hesperidin significantly increased the AUC5‐t and reduced the clearance of CPT‐11 and SN‐38, possibly by decreasing the hepatic expression of Mrp2, and thus inhibiting the biliary excretion of CPT‐11 and SN‐38.”
Effect of hesperidin on the pharmacokinetics of CPT‐11 and its active metabolite SN‐38 by regulating hepatic Mrp2 in rats
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