“… hesperidin could significantly promote tegaserod-induced …-HTR4 fluorescence intensity, intracellular calcium ions , relative protein of cAMP/PKA pathway and p-CREB pathway, and cell proliferation and inhibit GR113808-induced decrease of … intensity, 5-HTR4 pathway-related proteins (ADCY3, cAMP, PKA, and p-CREB), intracellular calcium ions, and cell proliferation.”