Possible Interaction: Hesperetin and Naringenin

“Interindividual variation in the plasma levels of hesperetin and naringenin was marked and, after the baseline and wash-out periods, and the low-vegetable diet, a majority of the samples had plasma flavanone levels below the limit of detection.”

“Combined treatment with naringenin and hesperetin also inhibited the migration (εCUP mimic condition, p < 0.001 for Panc-1 cells) of human pancreatic cancer cells.”

“RESULTS The plasma concentration of na ingenin an d hes peretin in Group A were significantly higher than Group B. CONCLUSIONS Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L. in the human body.”

“ Naringenin lowered mRNA levels of Tpo, Sod1, Sod2, Cat and Nrf2 by 50%, 32%, 45%, 35% and 42% (p<0.05), respectively, and increased Gpx by 54% (p<0.05), while hesperetin decreased Sod1 and Sod2 mRNA levels by 46% and 55% (p<0.05).”

“ Hesperetin and naringenin co-administration significantly enhanced the area under the curve (AUC), maximum plasma concentration (Cmax) and elimination half life (t1/2) of rasagiline with a concomitant reduction in clearance (CL/F) in both SDS and MDS.”

“ Hesperetin plus naringenin significantly decreased subepithelial fibrosis, smooth muscle hypertrophy in airways, and lung atelectasis compared with the AC group.”

“Our finding revealed that hesperetin plus naringenin ameliorate airway structural remodeling more than orange juice and grapefruit juice in murine model of HDM‐induced asthma.”

“The combination of hesperetin at 7 microM and naringenin at 3 microM resulted in better induction of nod gene activities compared to either hesperetin or naringenin alone.”