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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Hesperetin and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Hesperetin has been reported to increase the sensitivity of doxorubicin in breast cancer cells; however, the underlying molecular mechanism remains unclear.
Molecular Diversity  •  2019  |  View Paper
Further, hesperetin significantly reduced doxorubicin-induced DNA damage as well as apoptosis at 25, 50, and 100 mg/kg bw as evident from the comet and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assays, respectively.
Thus, hesperetin ameliorated doxorubicin-induced cardiotoxicity by reducing oxidative stress, abnormal cellular morphology and DNA damage in rat.
Cardiovascular Toxicology  •  2011  |  View Paper
The combination of Hst and Dox at the respective doses of 95 and 0,2 µM showed a synergistic effect with the combination index of 0,63.
Asian Pacific journal of cancer prevention : APJCP  •  2020  |  View Paper