“Results: Among the metabolites analyzed, omega-6 polyunsaturated fatty acids (linoleic acid, dihomo-gamma-linolenic acid, arachidonic … docosapentaenoic acid), omega-3 polyunsaturated fatty acids (docosahexaenoic acid, docosapentaenoic acid), aromatic amino acids (phenylalanine, tyrosine , tryptophan), and intermediates of the tricarboxylic acid cycle (…, isocitric acid) were significantly reduced during acute heroin ….”