supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Heroin
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Administration of 5 mg kg-1 DAM produced less antinociception in DAM-tolerant than DAM-naive rats and increased brain tryptophan concentration in both tolerant and naive rats.”
Tolerance to diacetyl morphine antinociception: effects on brain serotonin.“Results: Among the metabolites analyzed, omega-6 polyunsaturated fatty acids (linoleic acid, dihomo-gamma-linolenic acid, arachidonic … docosapentaenoic acid), omega-3 polyunsaturated fatty acids (docosahexaenoic acid, docosapentaenoic acid), aromatic amino acids (phenylalanine, tyrosine, tryptophan ), and intermediates of the tricarboxylic acid cycle (…, isocitric acid) were significantly reduced during acute heroin ….”
Plasma metabolites changes in male heroin addicts during acute and protracted withdrawal“Charged and polar residues (D, H , K, N, Q, R, S) are more incident in the immediate surrounding of tryptophan (-6, -5, -2, -1, 1, 2, 4) and hydrophobic residues (A, F, I, L, V, Y) are more rare than in remote positions.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback