“Results: Among the metabolites analyzed, omega-6 polyunsaturated fatty acids (linoleic …-linolenic acid, arachidonic acid, n-6 docosapentaenoic acid), omega-3 polyunsaturated fatty acids (docosahexaenoic acid, docosapentaenoic acid), aromatic amino acids (phenylalanine, tyrosine, tryptophan), and intermediates … tricarboxylic acid cycle (oxoglutaric acid, isocitric acid) were significantly reduced during acute heroin ….”