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Last Updated: 2 years ago

Possible Interaction: Heroin and Oxytocin

drug:

Heroin

supplement:

Oxytocin

Research Papers that Mention the Interaction

In rats, intravenous self-administration of heroin was potently decreased by OXT treatment.
Psychoneuroendocrinology  •  1998  |  View Paper
OXT inhibited the development of tolerance to morphine, heroin , beta-endorphin, and enkephalin, OXT also inhibited the development of cross-tolerance between the predominantly mu-agonist heroin and the predominantly delta-agonist enkephalin in mice.
Psychoneuroendocrinology  •  1994  |  View Paper
In the tolerant rats, on the other hand, oxytocin decreased the acquisition of heroin self-administration.
Life sciences  •  1985  |  View Paper
Single dose of OT decreased the level of cortisol and improved the cortisol/DHEAS ratio in the heroin users during abstinence (p < 0.01).
European Addiction Research  •  2019  |  View Paper
The preclinical research corroborates the clinical findings that systemic administration of oxytocin decreases relapse to cocaine, methamphetamine, heroin , and alcohol seeking (reviewed in [2]).
Thus far, reports from these trials demonstrate that oxytocin has some efficacy at reducing craving in alcohol, heroin and cocaine users.
Neuropsychopharmacology  •  2020  |  View Paper
It is concluded, therefore, that oxytocin interferes with mechanisms involved in the development and expression of tolerance to heroin.
Psychopharmacology  •  2004  |  View Paper
OXT weakened the processes of heroin self-administration, while ANT in contrast improved the learning.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova  •  1988  |  View Paper
In heroin-tolerant rats, the microinjection of OXT (2 ng) into the anterodorsal part of the nucleus accumbens or into the ventral hippocampus disrupted the self-administration of heroin.
It is concluded that limbic-mesolimbic brain structures have an essential role in the expression of the disruptive action of OXT on heroin self-administration.
The systemic injection of oxytocin (OXT) decreases the self-administration of heroin in heroin-tolerant rats.
Life sciences  •  1987  |  View Paper
Subcutaneous injection of oxytocin (OXT-(1-9)) and of its behaviorally active fragments desglycinamide9-oxytocin (OXT-(1-8)) and [pGlu4,Cyt6]-oxytocin-(4-8) (OXT-(4-8)) decreased the amount of heroin self-injected.
Life sciences  •  1985  |  View Paper
More importantly, clinical studies have also shown that OXT can exert beneficial effects on reducing substance use disorders of a series of drugs, such as heroin , cocaine, alcohol, cannabis and nicotine.
Pharmacology & therapeutics  •  2021  |  View Paper
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