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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Heroin and Melatonin

drug:

Heroin

supplement:

Melatonin

Research Papers that Mention the Interaction

Interestingly, N-acetylserotonin - a precursor of melatonin - was increased with the withdrawal of heroin while melatonin was markedly reduced along with the sub-chronic exposure to heroin.
This shows that heroin disrupts not only the energy metabolism but also the biosynthesis of both catecholamines and melatonin in the mouse brain.
Drug metabolism and pharmacokinetics  •  2017  |  View Paper