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Last Updated: 3 years ago

Possible Interaction: Heroin and Glutathione

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drug:

Heroin

supplement:

Glutathione

Research Papers that Mention the Interaction

“BACKGROUND Animal studies suggest that exposure to either of the two widely used drugs of abuse, heroin or cocaine, causes depletion of the antioxidant, reduced glutathione , a hallmark of oxidative stress, in the brain.”

Normal glutathione levels in autopsied brain of chronic users of heroin and of cocaine.

Drug and alcohol dependence • 2018 | View Paper

“Also, single-dose treatments of mice with heroin increased the total hepatic content of CYP, AHH, NADPH-cytochrome c reductase, and glutathione level by 126, 72, 39, 205%, respectively.”

Narcotic drugs change the expression of cytochrome P450 2E1 and 2C6 and other activities of carcinogen-metabolizing enzymes in the liver of male mice.

Toxicology • 2003 | View Paper

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