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Last Updated: 2 months ago

Possible Interaction: Heroin and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Heroin elevates dopamine levels in forebrain by blocking inhibitory GABA interneurons near the ventral tegmental area, leading to activation of mesocorticolimbic dopaminergic neurons (Nakagawa 2008, Steidl 2011).
CNS spectrums  •  2019  |  View Paper
Chemogenetic and optogenetic manipulations of VTA DA or GABA neurons establish a causal link to heroin reinforcement.
Likewise, heroin occluded the self-inhibition of VTA GABA neurons.
eLife  •  2018  |  View Paper
Acute administration of gamma-aminobutyric acid (GABA)-B receptor agonists decreases nicotine, cocaine, ethanol, and heroin self-administration and also decreases food-maintained responding and suppresses locomotor activity at high doses.
Journal of Pharmacology and Experimental Therapeutics  •  2008  |  View Paper
Heroin also reduced IC-evoked post-stimulus spike discharges, a manifestation of gap-junction-mediated electrical coupling between VTA GABA neurons.
The baseline firing rate of VTA GABA neurons significantly increased (239%) following the acquisition of heroin self-administration behavior and transiently increased during each response for heroin (105%), but decreased (49%) following heroin, similar to non-contingent heroin.
Experimental Neurology  •  2006  |  View Paper
Our findings confirm previous studies on the significance of mu-opioidergic mechanisms in … expression of heroin discrimination and add the observation that selective inhibition of GABA reuptake, but not inhibition of GABA transaminase or direct stimulation of …(A) and GABA(B) receptors, can decrease the overall effects of heroin.
Pharmacological reports : PR  •  2005  |  View Paper
Concentrations of the inhibitory amino acid GABA in ventral pallidal dialysates were significantly reduced within the first 10 min of heroin self-administration (0.02 mg per infusion; FR-1), and remained approximately 65% of presession baseline levels for the remainder of the 3-h self-administration session.
Thus, heroin self-administration is associated with both decreased GABA efflux and a late phase increase in glutamate efflux in the ventral pallidum.
The European journal of neuroscience  •  2004  |  View Paper
Heroin has been hypothesized to activate opiate receptors and inhibit gamma-aminobutyric acid (GABA) release from inhibitory GABAergic interneurons which, in turn, activates dopamine projection cells.
Magnetic resonance in medicine  •  2002  |  View Paper
Taken together, these experiments, for the first time, demonstrate that pharmacological elevation of mesolimbic GABA concentration blocks heroin reinforcement by activating GABA(B) receptors, supporting the GABAergic hypothesis of opiate reinforcement and the incorporation of GABA agents in opiate abuse treatment.
The Journal of pharmacology and experimental therapeutics  •  2000  |  View Paper
These findings indicate that gamma-vinyl GABA can interfere with the synergistic effects produced by the combination of an indirect dopamine releaser ( heroin ) and a dopamine reuptake blocker (cocaine).
European journal of pharmacology  •  1999  |  View Paper