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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heroin
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Both diamorphine and diamorphine with adrenaline provided significantly prolonged analgesia compared with control (mean time to next analgesia (95% confidence interval) 17.3 h (12.0, 22.1 h), 15.9 h (10.6, 21.1 h), 5.7 h (1.5, 9.9 h), respectively) (P < 0.01).”
Effect of extradural diamorphine on analgesia after caesarean section under subarachnoid block.“Multiple regression analysis showed that the addition of adrenaline significantly increased the duration of action of epidural diamorphine (p < 0.05).”
“The levels of counter-regulatory hormones in patients with H were significantly higher than during HRT (glucagon, p<0.05; epinephrine , p<0.01; cortisol, p<0.05; growth hormone, p<0.05).”
“ Epinephrine reduced absorption of diacetylmorphine from the extradural site by at least 55% over the first 30 min.”
“Significantly lower plasma morphine levels occurred between 3 and 20 min when epinephrine was added to diacetylmorphine.”
“The use of diacetylmorphine as a model for lipophilic opiates showed that addition of epinephrine not only reduced systemic absorption but also increased analgesic duration.”
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