“Results: Among the metabolites analyzed, omega-6 polyunsaturated … acid, dihomo-gamma-linolenic acid, arachidonic acid, n-6 docosapentaenoic acid ), omega-3 polyunsaturated fatty acids (docosahexaenoic acid, docosapentaenoic acid), aromatic amino acids (phenylalanine, tyrosine, tryptophan), … of the tricarboxylic acid cycle (oxoglutaric acid, isocitric acid) were significantly reduced during acute heroin ….”