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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heroin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Basal anxiety scores, cortisol and adrenocorticotropic hormone levels were higher in abstinent heroin users than in controls.”
Dysregulated responses to emotions among abstinent heroin users: Correlation with childhood neglect and addiction severity“ Heroin administration reduces craving, withdrawal, and anxiety levels and leads to significant decreases in ACTH and cortisol concentrations (P < 0.01).”
“Despite maintained performance capabilities, heroin addicts showed a blunted response of ACTH and a paradoxical decrease in endorphin levels.”
“The means of the two … fmol/ml, mean +/- SE), ACTH (2.… heroin addicts were significantly lower than those in controls (6.28 +/- 0.61, 10.1 +/- 0.74 and 364 +/- 27, … in heroin addicts (5.1 +/- 0.6) were similar to those of healthy volunteers (6.44 +/- 0.56).”
“During chronic withdrawal, HPA hormonal levels returned to baseline, but heroin challenge at 5 mg/kg decreased ACTH levels.”
Suppression of Hypothalamic–Pituitary–Adrenal Axis by Acute Heroin Challenge in Rats During Acute and Chronic Withdrawal from Chronic Heroin Administration
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