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“We also demonstrate an interaction between this heparin binding site and the zinc(II) binding site which is conserved in all members of the APP superfamily.”
Journal of molecular recognition : JMR • 1995 | View Paper
“Thus micromolar concentrations of zinc(II) appear to be able to modulate the binding of APP to heparin side‐chains of proteoglycans and as shown previously [Science 265 (1994) 1464–1467] to induce the aggregation of soluble amyloid βA4 protein.”