Possible Interaction: Heparin and Vitamin K

“Prolonged therapy of venous thromboembolism using unfractionated heparin or low-molecular-weight heparin followed by changing over to vitamin K antagonists is associated with decreased risk for thrombosis relapse approximately by 90%, however increasing the risk of haemorrhage.”

“Experiments performed on the solution of the mixture of VK1 and heparin show red shifts in both the channels on changing the concentration of both the analytes in the mixture.”

“Due to their properties, these drugs could gradually replace heparin and especially vitamin K antagonists.”

“Experience accumulated over the years has demonstrated that strict laboratory monitoring is required for unfractionated heparin and vitamin K antagonists, making use of these drugs problematic for patients and physicians and prompting researchers to develop new anticoagulants equally effective but without the requirement for laboratory monitoring.”

“ Heparin and anticoagulant therapy using vitamin K antagonists should be avoided in the acute phase.”

“The inhibition by heparin of lipoprotein‐mediated carriage of vitamin K and possibly other lipids to bone may provide a basis for the future understanding of heparin‐induced osteoporosis.”

“Although some emerging evidence has shown that patients receiving heparin bridging appear to be at increased risk of overall and major bleeding and at similar risk of thromboembolic events compared to controls, bridging therapy is still recommended for patients on vitamin K antagonists who are at high thrombotic risk.”

“Both vitamin K antagonists and heparins may be associated with maternal and foetal adverse events.”