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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Heparin and Tyrosine

drug:

Heparin

supplement:

Tyrosine

Research Papers that Mention the Interaction

We demonstrate that sFRP-1 is post-translationally modified by tyrosine sulfation at tyrosines 34 and 36, which is inhibited by the treatment of heparin.
Journal of Biological Chemistry  •  2007  |  View Paper
The tyrosine phosphorylation of a group of proteins was increased in the presence of heparin.
Biology of reproduction  •  1999  |  View Paper
Western blot analysis with anti‐phosphotyrosine antibodies shows that heparin specifically alters the tyrosine phosphorylation of only two proteins (42 kDa and 200 kDa).
Journal of cellular physiology  •  1999  |  View Paper
Heparin failed to alter 5-HT uptake by SMC, but inhibited the stimulation of tyrosine phosphorylation of GTPase-activating protein, a proposed intermediate in the 5-HT stimulatory process.
American journal of respiratory cell and molecular biology  •  1997  |  View Paper
Heparin activation of FGFR‐4 or of a chimeric receptor bearing FGFR‐4 ectodomain and FGFR‐1 cytodomain triggers downstream tyrosine phosphorylation of several signaling proteins, and induces proliferation of cells bearing the chimeric receptor.
The EMBO journal  •  1995  |  View Paper
The constituent lysyltyrosyl (but not lysylphenylalanyl) peptide inhibited tyrosine hydroxylase, and heparin also reversed this inhibition, which was sigmoidal (IC50 of 490 μM) and partially competitive with tyrosine.
Journal of neurochemistry  •  1980  |  View Paper
At the same time, heparin , which activates the native striatal enzyme (Ka = 9 µg per ml), inhibits the trypsin-treated enzyme competitive with tyrosine (Ki = 19 µg per ml).
The Journal of biological chemistry  •  1973  |  View Paper
Also, poly L-lysine and heparin inhibited tyrosine phosphorylation by 57 kDa maize protein kinase.
Acta biochimica Polonica  •  2004  |  View Paper