Possible Interaction: Heparin and Tyrosine

“We demonstrate that sFRP-1 is post-translationally modified by tyrosine sulfation at tyrosines 34 and 36, which is inhibited by the treatment of heparin.”

“The tyrosine phosphorylation of a group of proteins was increased in the presence of heparin.”

“Western blot analysis with anti‐phosphotyrosine antibodies shows that heparin specifically alters the tyrosine phosphorylation of only two proteins (42 kDa and 200 kDa).”

“ Heparin failed to alter 5-HT uptake by SMC, but inhibited the stimulation of tyrosine phosphorylation of GTPase-activating protein, a proposed intermediate in the 5-HT stimulatory process.”

“ Heparin activation of FGFR‐4 or of a chimeric receptor bearing FGFR‐4 ectodomain and FGFR‐1 cytodomain triggers downstream tyrosine phosphorylation of several signaling proteins, and induces proliferation of cells bearing the chimeric receptor.”

“The constituent lysyltyrosyl (but not lysylphenylalanyl) peptide inhibited tyrosine hydroxylase, and heparin also reversed this inhibition, which was sigmoidal (IC50 of 490 μM) and partially competitive with tyrosine.”

“At the same time, heparin , which activates the native striatal enzyme (Ka = 9 µg per ml), inhibits the trypsin-treated enzyme competitive with tyrosine (Ki = 19 µg per ml).”

“Also, poly L-lysine and heparin inhibited tyrosine phosphorylation by 57 kDa maize protein kinase.”