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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heparin
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“ HEP more strongly interacts with HSA than DS.”
Specific volume and compressibility of human serum albumin-polyanion complexes.“The effects of heparin were dependent on its specific binding to HSA , which triggered an oxidative mechanism strikingly different from that caused by glucose.”
“The results demonstrate that the oxidative mechanism sustained by heparin mediates biological effects that may be beneficial in reducing the extent of glycooxidative damage on HSA.”
“In the present study we demonstrate that heparin largely reduces Suc-HSA activity on HIV replication in the same concentration in which if affects binding of Suc-HSA to the envelope protein gp120 and in particular its V3 domain.”
“In the same concentration range, heparin reduced binding of Suc-HSA to MT4 cells, another HTLV-I-transformed cell line.”
“It is concluded that heparin can displace Suc-HSA from its binding sites on hybrid lymphoid cells as well as on HIV-1 particles.”
“The antagonistic effect by heparin was observed both in the case that heparin was added prior to or after addition of Suc-HSA to the test system.”
“The fact that heparin and heparin degradation products antagonize Suc-HSA without having a significant anti-HIV-1 effect indicates that the anticoagulant acts as a relatively weak partial inhibitor.”
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