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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heparin
supplement:
Polypeptides
Research Papers that Mention the Interaction
“The polypeptide required interaction with heparin for activity, demonstrating the importance of heparin for FGFR activation even with designed ligands structurally unrelated to FGF.”
Semirational design of a potent, artificial agonist of fibroblast growth factor receptors“It is concluded that the sulfatase activity in some types of breast cancer cell can be inhibited by heparin combined with the polypeptides Decapeptyl or TGF-alpha.”
“It has been shown that dextran sulfate, heparin , denatured DNA and poly I inhibited the binding of autoantibodies with some polypeptides.”
“ Heparin interacts structurally with ECGF [Maciag, T., Mehlman, T., Friesel, R. & Schreiber, A. B. (1984) Science 225, 932-935], potentiates the mitogenic activity of the polypeptide , restores the biological activity to inactivate ECGF, enhances the affinity of the ligand to cell surface receptors, and modifies antibody recognition of ECGF.”
“The phosphorylation of both the 55-kDa polypeptide and exogenously added casein was inhibited with GTP, heparin , and 2,3-bisphosphoglycerate in a dose-dependent manner, indicating the involvement of a CK2-like protein kinase.”
Trypanosoma cruzi: in vitro phosphorylation of tubulin by a protein kinase CK2-like enzyme.“ Heparin (10 U/ml) and dextran sulfate (100 mg/ml) inhibited the contractile effect of cationic polypeptides but did not affect contractions to phorbol 12,13-dibutyrate.”
“These results suggest that heparin , via its antiproliferative rather than anticoagulant effect, can inhibit mesangial cell proliferation, overexpression of polypeptide growth factors, and ECM protein overproduction in vivo.”
“Mutant NCAM polypeptides purified from transfected cell lines have substantially reduced binding to heparin and fail to promote chick retinal cell attachment.”
“Heparan and keratan sulfates failed to activate tyrosine hydroxylase in place of heparin; several fractions of the bulk heparin (constituting 5 and 15%) had enriched tyrosine hydroxylase‐activating potency; and two lysine copolypeptides (polylysyltyrosine and polylysylphenylalanine) inhibited the activation of tyrosine hydroxylase by heparin.”
“The basic L-lysine polypeptides prolonged whole blood clotting time, increased prothrombin time and neutralized the effect of heparin.”
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