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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“… heparin … papain specifically; this interaction induces an increase of its α-helix content and stabilizes the enzyme structure even at alkaline pH (Almeida, P. C., Nantes, …. C. A., Júdice, W. A. S., Chagas, J. R., Juliano, L., Nader, H. B., and Tersariol, I. L. S. (1999) J. Biol.”
Cathepsin B Activity Regulation“Approximately stoichiometric amounts of heparin completely inhibited the reaction of papain with antithrombin.”
“For tablets based on heparin/papain/HEC, a relative bioavailability of 9.1% vs. subcutaneous injection was obtained, whereas the relative bioavailability of control was 2.4%.ConclusionThe co-administration of papain with heparin represents a new approach in improvement of absorption and bioavailability of orally administered heparin.”
“The results of binding studies of papain with heparin indicated a strong interaction between papain and heparin.”
Papain: An Effective Permeation Enhancer for Orally Administered Low Molecular Weight Heparin“The incubation of papain with heparin promoted a powerful increase in the affinity of the enzyme for the substrate.”
“The interaction of heparin and other glycosaminoglycans with papain may be representative of many mammalian cysteine proteinase-glycosaminoglycan interactions that can regulate the function of this class of proteinases in vivo.”
“The presence of heparin significantly increases the α-helix content of papain.”
Cysteine Proteinase Activity Regulation
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