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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Heparin and Leucine

drug:

Heparin

supplement:

Leucine

Research Papers that Mention the Interaction

Addition of leucine improved fine particle fraction of heparin and pentoxifylline.
International journal of pharmaceutics  •  2010  |  View Paper
The presence of heparin accelerated inhibition of cathepsin L by both serpins, and in the case of SCCA-1, heparin increased the second order inhibition rate constant from 5.4 × 105 to >108, indicating a rate enhancement of at least 180-fold.
The Journal of Biological Chemistry  •  2009  |  View Paper
We show that heparin reduces the stability of the pro form of cathepsin L at pH 5 by binding to a putative heparin binding motif (BBXB) in the pro-domain.
Biochemical and biophysical research communications  •  2008  |  View Paper
Rheological analysis has shown that spray-dried UFH and UFH cospray-dried with L-leucine significantly (p < 0.05) reduce the elasticity and yield stress of CF sputum.
Journal of pharmaceutical sciences  •  2008  |  View Paper
We hypothesized that UFH reduces LEU brain tissue sequestration resulting in prolonged cognitive recovery.
The journal of trauma and acute care surgery  •  2017  |  View Paper
After intraperitoneal injection of [3H]leucine the incorporated radioactivity was slightly increased in unfractionated brains from EAE animals.
Brain Research  •  1975  |  View Paper
It is also suggested that the strong inhibitory action of heparin on the interaction of the L variant with cells may be another factor aiding its rapid spread in vivo.
Virology  •  1967  |  View Paper