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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Heparin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Treatment of mice with pharmacologic doses of heparin inhibited liver hepcidin mRNA expression and SMAD phosphorylation, reduced spleen iron concentration, and increased serum iron.”
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo.“Across all systemic medication exposures, heparin use was associated with lower erythropoiesis stimulating agent (ESA) dose, higher hemoglobin levels, and lower monthly intravenous (IV) iron dose ; lower rates of clotting during treatment and hospitalization for GI bleeding; and similar rates of peri-treatment bleeding.”
“ Iron loading resulted in a sharp increase in the total activity of the lysosomal enzyme beta-hexosaminidase in unfractionated whole-cell homogenates, increased free enzyme activity, and loss of latent activity indicating increased lysosomal fragility.”
Iron loading of cultured cardiac myocytes modifies sarcolemmal structure and increases lysosomal fragility.
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