Possible Interaction: Heparin and Intralipid

“Studies in which both untrained and well-trained … ingested LCT solutions or received an infusion of intralipid (in combination with … injection of heparin ) before exercise have reported significant reductions in whole-body carbohydrate oxidation and decreased … glycogen utilization during both moderate and intense dynamic exercise lasting 15-60 min.”

“In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure.”

“The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 +/- 2.1 mmHg) and diastolic (8.0 +/- 1.5 mmHg) blood pressure as well as heart rate (9.4 +/- 1.4 beats/min).”

“The local infusion of Intralipid with heparin reduced hand vein distensibility, whereas dextrose and heparin did not (11 +/- 3% vs. 0 +/- 2%, respectively, P < 0.01).”

“In a … = 8) when heparin … Intralipid were infused without insulin, FFA levels rose approximately twofold (0.53 +/- 0.04 to 0.85 +/- 0.1 mmol/liter), VLDL triglyceride … 180.1 +/- 45.7% (P = 0.008) and VLDL apo B production increased by 94.2 +/- 28.7% (P = 0.05).”

“Prior subcutaneous injection of 5000 U of heparin did not affect either immunological parameter, but completely prevented the changes in monocyte function caused by Intralipid.”

“In chronically catheterized conscious rats, the short-term elevation of plasma FFAs by the 5-h infusion of heparin plus Intralipid decreased muscle protein synthesis by approximately 25% under basal conditions.”

“Administration … of Intralipid (500 microliters at -30 min … at -25 min) plus heparin (50 IU at -15 min) induced a marked decrease in GH responses to both 1 and 5 micrograms/… (p less than 0.01 at 5, 10 and 15 min for GHRH alone vs. GHRH plus Intralipid).”

“High plasma FFA levels were induced either by intravenous injection of Intralipid and heparin , or by infusion of norepinephrine.”